The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives

A new series of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine (PTP) derivatives has been developed in order to explore their affinity and selectivity profile at the four adenosine receptor subtypes. In particular, the PTP scaffold was conjugated at the C2 position with the 1-(3-trifluoromethyl-ben...

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Veröffentlicht in:PLoS One
Hauptverfasser: Federico, Stephanie, Redenti, Sara, Sturlese, Mattia, Ciancetta, Antonella, Kachler, Sonja, Klotz, Karl-Norbert, Cacciari, Barbara, Moro, Stefano, Spalluto, Giampiero
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666649/
https://ncbi.nlm.nih.gov/pubmed/26625265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143504
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