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Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain

Allosteric regulation of protein function is a critical component of metabolic control. Its importance is underpinned by the diversity of mechanisms and its presence in all three domains of life. The first enzyme of the aromatic amino acid biosynthesis, 3-deoxy-D-arabino-heptulosonate 7-phosphate sy...

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Detalles Bibliográficos
Main Authors: Cross, Penelope J., Allison, Timothy M., Dobson, Renwick C. J., Jameson, Geoffrey B., Parker, Emily J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568362/
https://ncbi.nlm.nih.gov/pubmed/23345433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217923110
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