Tyrosine Latching of a Regulatory Gate Affords Allosteric Control of Aromatic Amino Acid Biosynthesis

The first step of the shikimate pathway for aromatic amino acid biosynthesis is catalyzed by 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS). Thermotoga maritima DAH7PS (TmaDAH7PS) is tetrameric, with monomer units comprised of a core catalytic (β/α)(8) barrel and an N-terminal domain....

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Hlavní autoři: Cross, Penelope J., Dobson, Renwick C. J., Patchett, Mark L., Parker, Emily J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060475/
https://ncbi.nlm.nih.gov/pubmed/21282100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.209924
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