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Domain cross-talk within a bifunctional enzyme provides catalytic and allosteric functionality in the biosynthesis of aromatic amino acids

Because of their special organization, multifunctional enzymes play crucial roles in improving the performance of metabolic pathways. For example, the bacterium Prevotella nigrescens contains a distinctive bifunctional protein comprising a 3-deoxy-d-arabino heptulosonate-7-phosphate synthase (DAH7PS...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Bai, Yu, Lang, Eric J. M., Nazmi, Ali Reza, Parker, Emily J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442060/
https://ncbi.nlm.nih.gov/pubmed/30670586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005220
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