Synergistic Allostery, a Sophisticated Regulatory Network for the Control of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis

The shikimate pathway, responsible for aromatic amino acid biosynthesis, is required for the growth of Mycobacterium tuberculosis and is a potential drug target. The first reaction is catalyzed by 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS). Feedback regulation of DAH7PS activity b...

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Bibliografische gegevens
Hoofdauteurs: Webby, Celia J., Jiao, Wanting, Hutton, Richard D., Blackmore, Nicola J., Baker, Heather M., Baker, Edward N., Jameson, Geoffrey B., Parker, Emily J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2010
Onderwerpen:
Enzymology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945551/
https://ncbi.nlm.nih.gov/pubmed/20667835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.111856
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