Complex Formation between Two Biosynthetic Enzymes Modifies the Allosteric Regulatory Properties of Both: AN EXAMPLE OF MOLECULAR SYMBIOSIS

Allostery, where remote ligand binding alters protein function, is essential for the control of metabolism. Here, we have identified a highly sophisticated allosteric response that allows complex control of the pathway for aromatic amino acid biosynthesis in the pathogen Mycobacterium tuberculosis....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Blackmore, Nicola J., Nazmi, Ali Reza, Hutton, Richard D., Webby, Melissa N., Baker, Edward N., Jameson, Geoffrey B., Parker, Emily J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505062/
https://ncbi.nlm.nih.gov/pubmed/26032422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.638700
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