LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance

Hematopoietic stem cells (HSCs) are the most primitive cells in the hematopoietic system and are under tight regulation for self-renewal and differentiation. Notch signals are essential for the emergence of definitive hematopoiesis in mouse embryos and are critical regulators of lymphoid lineage fat...

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Bibliographic Details
Main Authors: Lee, Sung-Uk, Maeda, Manami, Ishikawa, Yuichi, Li, Sierra Min, Wilson, Anne, Jubb, Adrian M., Sakurai, Nagisa, Weng, Lihong, Fiorini, Emma, Radtke, Freddy, Yan, Minhong, MacDonald, H. Robson, Chen, Ching-Cheng, Maeda, Takahiro
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2013
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567339/
https://ncbi.nlm.nih.gov/pubmed/23134786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-418103
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