Dll1- and Dll4-mediated Notch signaling is required for homeostasis of intestinal stem cells

BACKGROUND & AIMS: Ablation of Notch signaling within the intestinal epithelium results in loss of proliferating crypt progenitors, due to their conversion into post-mitotic secretory cells. We aimed to confirm that Notch was active in stem cells (SC), investigate consequences of loss of Notch s...

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Detalhes bibliográficos
Main Authors: Pellegrinet, Luca, Rodilla, Veronica, Liu, Zhenyi, Chen, Shuang, Koch, Ute, Espinosa, Lluis, Kaestner, Klaus H., Kopan, Raphael, Lewis, Julian, Radtke, Freddy
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066401/
https://ncbi.nlm.nih.gov/pubmed/21238454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.01.005
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