Heterozygous inactivation of the Nf1 gene in myeloid cells enhances neointima formation via a rosuvastatin-sensitive cellular pathway

Mutations in the NF1 tumor suppressor gene cause Neurofibromatosis type 1 (NF1). Neurofibromin, the protein product of NF1, functions as a negative regulator of Ras activity. Some NF1 patients develop cardiovascular disease, which represents an underrecognized disease complication and contributes to...

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Hlavní autoři: Stansfield, Brian K., Bessler, Waylan K., Mali, Raghuveer, Mund, Julie A., Downing, Brandon, Li, Fang, Sarchet, Kara N., DiStasi, Matthew R., Conway, Simon J., Kapur, Reuben, Ingram, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561913/
https://ncbi.nlm.nih.gov/pubmed/23197650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds502
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