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The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response

Recent studies suggest that the sterol metabolic network participates in the interferon (IFN) antiviral response. However, the molecular mechanisms linking IFN with the sterol network and the identity of sterol mediators remain unknown. Here we report a cellular antiviral role for macrophage product...

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Detalhes bibliográficos
Main Authors: Blanc, Mathieu, Hsieh, Wei Yuan, Robertson, Kevin A., Kropp, Kai A., Forster, Thorsten, Shui, Guanghou, Lacaze, Paul, Watterson, Steven, Griffiths, Samantha J., Spann, Nathanael J., Meljon, Anna, Talbot, Simon, Krishnan, Kathiresan, Covey, Douglas F., Wenk, Markus R., Craigon, Marie, Ruzsics, Zsolts, Haas, Jürgen, Angulo, Ana, Griffiths, William J., Glass, Christopher K., Wang, Yuqin, Ghazal, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556782/
https://ncbi.nlm.nih.gov/pubmed/23273843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.11.004
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