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Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon- [Formula: see text] in primary macrophages requires endogenous 25-hydroxycholesterol synthesis
Interferons (IFNs) play a central role in immunity and emerging evidence suggests that IFN-signalling coordinately regulates sterol biosynthesis in macrophages, via Sterol Regulatory Element-Binding Protein (SREBP) dependent and independent pathways. However, the precise mechanisms and kinetic steps...
Gorde:
| Argitaratua izan da: | Steroids |
|---|---|
| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Elsevier
2015
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4503878/ https://ncbi.nlm.nih.gov/pubmed/25759117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2015.02.022 |
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