The in silico macrophage: toward a better understanding of inflammatory disease

Por Ghazal, Peter, Watterson, Steven, Robertson, Kevin, Kluth, David C
Publicado em 2011

The genetics and screening of familial hypercholesterolaemia

Por Henderson, Raymond, O’Kane, Maurice, McGilligan, Victoria, Watterson, Steven
Publicado no J Biomed Sci (2016)

A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway

Por Mazein, Alexander, Watterson, Steven, Hsieh, Wei-Yuan, Griffiths, William J., Ghazal, Peter
Publicado em 2013

Corrigendum for the paper ‘Digital clocks: simple Boolean models can quantitatively describe circadian systems’

Por Akman, Ozgur E., Watterson, Steven, Parton, Andrew, Binns, Nigel, Millar, Andrew J., Ghazal, Peter
Publicado em 2012

Digital clocks: simple Boolean models can quantitatively describe circadian systems

Por Akman, Ozgur E., Watterson, Steven, Parton, Andrew, Binns, Nigel, Millar, Andrew J., Ghazal, Peter
Publicado em 2012

Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon- [Formula: see text] in primary macrophages requires endogenous 25-hydroxycholesterol synthe...

Por Lu, Hongjin, Talbot, Simon, Robertson, Kevin A., Watterson, Steven, Forster, Thorsten, Roy, Douglas, Ghazal, Peter
Publicado no Steroids (2015)

Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway

Por Benson, Helen E, Watterson, Steven, Sharman, Joanna L, Mpamhanga, Chido P, Parton, Andrew, Southan, Christopher, Harmar, Anthony J, Ghazal, Peter
Publicado no Br J Pharmacol (2017)

A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction

Por Watterson, Steven, Guerriero, Maria Luisa, Blanc, Mathieu, Mazein, Alexander, Loewe, Laurence, Robertson, Kevin A., Gibbs, Holly, Shui, Guanghou, Wenk, Markus R., Hillston, Jane, Ghazal, Peter
Publicado em 2013

Construction of a large scale integrated map of macrophage pathogen recognition and effector systems

Por Raza, Sobia, McDerment, Neil, Lacaze, Paul A, Robertson, Kevin, Watterson, Steven, Chen, Ying, Chisholm, Michael, Eleftheriadis, George, Monk, Stephanie, O'Sullivan, Maire, Turnbull, Arran, Roy, Douglas, Theocharidis, Athanasios, Ghazal, Peter, Freeman, Tom C
Publicado em 2010

Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis

Por Blanc, Mathieu, Hsieh, Wei Yuan, Robertson, Kevin A., Watterson, Steven, Shui, Guanghou, Lacaze, Paul, Khondoker, Mizanur, Dickinson, Paul, Sing, Garwin, Rodríguez-Martín, Sara, Phelan, Peter, Forster, Thorsten, Strobl, Birgit, Müller, Matthias, Riemersma, Rudolph, Osborne, Timothy, Wenk, Markus R., Angulo, Ana, Ghazal, Peter
Publicado em 2011

An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway

Por Robertson, Kevin A., Hsieh, Wei Yuan, Forster, Thorsten, Blanc, Mathieu, Lu, Hongjin, Crick, Peter J., Yutuc, Eylan, Watterson, Steven, Martin, Kimberly, Griffiths, Samantha J., Enright, Anton J., Yamamoto, Mami, Pradeepa, Madapura M., Lennox, Kimberly A., Behlke, Mark A., Talbot, Simon, Haas, Jürgen, Dölken, Lars, Griffiths, William J., Wang, Yuqin, Angulo, Ana, Ghazal, Peter
Publicado no PLoS Biol (2016)

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response

Por Blanc, Mathieu, Hsieh, Wei Yuan, Robertson, Kevin A., Kropp, Kai A., Forster, Thorsten, Shui, Guanghou, Lacaze, Paul, Watterson, Steven, Griffiths, Samantha J., Spann, Nathanael J., Meljon, Anna, Talbot, Simon, Krishnan, Kathiresan, Covey, Douglas F., Wenk, Markus R., Craigon, Marie, Ruzsics, Zsolts, Haas, Jürgen, Angulo, Ana, Griffiths, William J., Glass, Christopher K., Wang, Yuqin, Ghazal, Peter
Publicado em 2013