A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction

The cholesterol biosynthesis pathway has recently been shown to play an important role in the innate immune response to viral infection with host protection occurring through a coordinate down regulation of the enzymes catalysing each metabolic step. In contrast, statin based drugs, which form the p...

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Detalhes bibliográficos
Main Authors: Watterson, Steven, Guerriero, Maria Luisa, Blanc, Mathieu, Mazein, Alexander, Loewe, Laurence, Robertson, Kevin A., Gibbs, Holly, Shui, Guanghou, Wenk, Markus R., Hillston, Jane, Ghazal, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Editions Scientifiques Elsevier 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585962/
https://ncbi.nlm.nih.gov/pubmed/22664637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2012.05.024
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