A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction

The cholesterol biosynthesis pathway has recently been shown to play an important role in the innate immune response to viral infection with host protection occurring through a coordinate down regulation of the enzymes catalysing each metabolic step. In contrast, statin based drugs, which form the p...

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Bibliographic Details
Main Authors: Watterson, Steven, Guerriero, Maria Luisa, Blanc, Mathieu, Mazein, Alexander, Loewe, Laurence, Robertson, Kevin A., Gibbs, Holly, Shui, Guanghou, Wenk, Markus R., Hillston, Jane, Ghazal, Peter
Format: Artigo
Language:Inglês
Published: Editions Scientifiques Elsevier 2013
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585962/
https://ncbi.nlm.nih.gov/pubmed/22664637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2012.05.024
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