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Predicting Enhanced Cell Killing through PARP Inhibition

PARP inhibitors show promise as combination and single agents in cancer chemotherapy. Here, we evaluate results obtained with mouse fibroblasts and the common laboratory PARP inhibitor, 4-amino-1,8-naphthalimide (4-AN), and analyze the potential for enhanced cytotoxicity following the combination of...

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Detalles Bibliográficos
Main Authors: Horton, Julie K., Wilson, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552016/
https://ncbi.nlm.nih.gov/pubmed/23193155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0512
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