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Predicting Enhanced Cell Killing through PARP Inhibition

PARP inhibitors show promise as combination and single agents in cancer chemotherapy. Here, we evaluate results obtained with mouse fibroblasts and the common laboratory PARP inhibitor, 4-amino-1,8-naphthalimide (4-AN), and analyze the potential for enhanced cytotoxicity following the combination of...

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Detalhes bibliográficos
Main Authors: Horton, Julie K., Wilson, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552016/
https://ncbi.nlm.nih.gov/pubmed/23193155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0512
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