Base excision repair defects invoke hypersensitivity to PARP inhibition

Poly (ADP-ribose) polymerase-1 (PARP-1) is important for the recognition of both endogenous and exogenous DNA damage, and binds to DNA strand-breaks including intermediates of base excision repair (BER). Once DNA-bound, PARP-1 becomes catalytically activate synthesizing poly-ADP-ribose (PAR) polymer...

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Autori principali: Horton, Julie K., Stefanick, Donna F., Prasad, Rajendra, Gassman, Natalie R., Kedar, Padmini S., Wilson, Samuel H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135006/
https://ncbi.nlm.nih.gov/pubmed/24770870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0502
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