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Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition
Inhibition of PARP activity results in extreme sensitization to MMS-induced cell killing in cultured mouse fibroblasts. In these MMS-treated cells, PARP inhibition is accompanied by an accumulation of S-phase cells that requires signaling by the checkpoint kinase ATR (Horton et al. (2005) J. Biol. C...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2585487/ https://ncbi.nlm.nih.gov/pubmed/18691676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2008.07.006 |
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