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Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition

Inhibition of PARP activity results in extreme sensitization to MMS-induced cell killing in cultured mouse fibroblasts. In these MMS-treated cells, PARP inhibition is accompanied by an accumulation of S-phase cells that requires signaling by the checkpoint kinase ATR (Horton et al. (2005) J. Biol. C...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Kedar, Padmini S., Stefanick, Donna F., Horton, Julie K., Wilson, Samuel H.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585487/
https://ncbi.nlm.nih.gov/pubmed/18691676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2008.07.006
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