Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair

Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme in mammalian cells. The enzyme synthesizes polymers of ADP-ribose from the coenzyme NAD(+) and plays multifaceted roles in cellular responses to genotoxic stress, including DNA repair. It had been shown that mouse fibroblasts treat...

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Autores principales: Prasad, Rajendra, Horton, Julie K., Chastain, Paul D., Gassman, Natalie R., Freudenthal, Bret D., Hou, Esther W., Wilson, Samuel H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041460/
https://ncbi.nlm.nih.gov/pubmed/24771347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku288
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