PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1

PARP1-dependent poly-ADP-ribosylation (PARylation) participates in the repair of many forms of DNA damage. Here, we used atomic force microscopy (AFM) and single molecule fluorescence microscopy to examine the interactions of PARP1 with common DNA repair intermediates. AFM volume analysis indicates...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Liu, Lili, Kong, Muwen, Gassman, Natalie R., Freudenthal, Bret D., Prasad, Rajendra, Zhen, Stephanie, Watkins, Simon C., Wilson, Samuel H., Van Houten, Bennett
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728402/
https://ncbi.nlm.nih.gov/pubmed/29121337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1047
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