PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1

PARP1-dependent poly-ADP-ribosylation (PARylation) participates in the repair of many forms of DNA damage. Here, we used atomic force microscopy (AFM) and single molecule fluorescence microscopy to examine the interactions of PARP1 with common DNA repair intermediates. AFM volume analysis indicates...

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Publicat a:Nucleic Acids Res
Autors principals: Liu, Lili, Kong, Muwen, Gassman, Natalie R., Freudenthal, Bret D., Prasad, Rajendra, Zhen, Stephanie, Watkins, Simon C., Wilson, Samuel H., Van Houten, Bennett
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728402/
https://ncbi.nlm.nih.gov/pubmed/29121337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1047
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