PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1

PARP1-dependent poly-ADP-ribosylation (PARylation) participates in the repair of many forms of DNA damage. Here, we used atomic force microscopy (AFM) and single molecule fluorescence microscopy to examine the interactions of PARP1 with common DNA repair intermediates. AFM volume analysis indicates...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Nucleic Acids Res
Päätekijät: Liu, Lili, Kong, Muwen, Gassman, Natalie R., Freudenthal, Bret D., Prasad, Rajendra, Zhen, Stephanie, Watkins, Simon C., Wilson, Samuel H., Van Houten, Bennett
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2017
Aiheet:
Genome Integrity, Repair and Replication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728402/
https://ncbi.nlm.nih.gov/pubmed/29121337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1047
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