Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching

DNA double-strand breaks (DSBs) are byproducts of normal cellular metabolism and obligate intermediates in antigen receptor diversification reactions. These lesions are potentially dangerous because they can lead to deletion of genetic material or chromosome translocation. The chromatin-binding prot...

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Bibliografische gegevens
Hoofdauteurs: Bothmer, Anne, Rommel, Philipp C., Gazumyan, Anna, Polato, Federica, Reczek, Colleen R., Muellenbeck, Matthias F., Schaetzlein, Sonja, Edelmann, Winfried, Chen, Phang-Lang, Brosh, Robert M., Casellas, Rafael, Ludwig, Thomas, Baer, Richard, Nussenzweig, André, Nussenzweig, Michel C., Robbiani, Davide F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549709/
https://ncbi.nlm.nih.gov/pubmed/23254285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121975
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