Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of paclitaxel-induced sensory peripheral neuropathy

PURPOSE: We sought to demonstrate the relevance of a lymphoblastoid cell line (LCL) model in the discovery of clinically relevant genetic variants affecting chemotherapeutic response by comparing LCL genome-wide association study (GWAS) results to clinical GWAS results. EXPERIMENTAL DESIGN: A GWAS o...

Deskribapen osoa

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Xehetasun bibliografikoak
Egile Nagusiak: Wheeler, Heather E., Gamazon, Eric R., Wing, Claudia, Njiaju, Uchenna O., Njoku, Chidiamara, Baldwin, R. Michael, Owzar, Kouros, Jiang, Chen, Watson, Dorothy, Shterev, Ivo, Kubo, Michiaki, Zembutsu, Hitoshi, Winer, Eric, Hudis, Clifford, Shulman, Lawrence N., Nakamura, Yusuke, Ratain, Mark J., Kroetz, Deanna L., Cox, Nancy J., Dolan, M. Eileen
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549006/
https://ncbi.nlm.nih.gov/pubmed/23204130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2618
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