Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of paclitaxel-induced sensory peripheral neuropathy

PURPOSE: We sought to demonstrate the relevance of a lymphoblastoid cell line (LCL) model in the discovery of clinically relevant genetic variants affecting chemotherapeutic response by comparing LCL genome-wide association study (GWAS) results to clinical GWAS results. EXPERIMENTAL DESIGN: A GWAS o...

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Autors principals: Wheeler, Heather E., Gamazon, Eric R., Wing, Claudia, Njiaju, Uchenna O., Njoku, Chidiamara, Baldwin, R. Michael, Owzar, Kouros, Jiang, Chen, Watson, Dorothy, Shterev, Ivo, Kubo, Michiaki, Zembutsu, Hitoshi, Winer, Eric, Hudis, Clifford, Shulman, Lawrence N., Nakamura, Yusuke, Ratain, Mark J., Kroetz, Deanna L., Cox, Nancy J., Dolan, M. Eileen
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549006/
https://ncbi.nlm.nih.gov/pubmed/23204130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2618
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