Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of paclitaxel-induced sensory peripheral neuropathy

PURPOSE: We sought to demonstrate the relevance of a lymphoblastoid cell line (LCL) model in the discovery of clinically relevant genetic variants affecting chemotherapeutic response by comparing LCL genome-wide association study (GWAS) results to clinical GWAS results. EXPERIMENTAL DESIGN: A GWAS o...

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Bibliografski detalji
Glavni autori: Wheeler, Heather E., Gamazon, Eric R., Wing, Claudia, Njiaju, Uchenna O., Njoku, Chidiamara, Baldwin, R. Michael, Owzar, Kouros, Jiang, Chen, Watson, Dorothy, Shterev, Ivo, Kubo, Michiaki, Zembutsu, Hitoshi, Winer, Eric, Hudis, Clifford, Shulman, Lawrence N., Nakamura, Yusuke, Ratain, Mark J., Kroetz, Deanna L., Cox, Nancy J., Dolan, M. Eileen
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549006/
https://ncbi.nlm.nih.gov/pubmed/23204130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2618
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