Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of paclitaxel-induced sensory peripheral neuropathy

PURPOSE: We sought to demonstrate the relevance of a lymphoblastoid cell line (LCL) model in the discovery of clinically relevant genetic variants affecting chemotherapeutic response by comparing LCL genome-wide association study (GWAS) results to clinical GWAS results. EXPERIMENTAL DESIGN: A GWAS o...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Wheeler, Heather E., Gamazon, Eric R., Wing, Claudia, Njiaju, Uchenna O., Njoku, Chidiamara, Baldwin, R. Michael, Owzar, Kouros, Jiang, Chen, Watson, Dorothy, Shterev, Ivo, Kubo, Michiaki, Zembutsu, Hitoshi, Winer, Eric, Hudis, Clifford, Shulman, Lawrence N., Nakamura, Yusuke, Ratain, Mark J., Kroetz, Deanna L., Cox, Nancy J., Dolan, M. Eileen
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2012
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549006/
https://ncbi.nlm.nih.gov/pubmed/23204130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2618
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