SCG10 is a JNK target in the axonal degeneration pathway

Axons actively self-destruct following genetic, mechanical, metabolic, and toxic insults, but the mechanism of axonal degeneration is poorly understood. The JNK pathway promotes axonal degeneration shortly after axonal injury, hours before irreversible axon fragmentation ensues. Inhibition of JNK ac...

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Autors principals: Shin, Jung Eun, Miller, Bradley R., Babetto, Elisabetta, Cho, Yongcheol, Sasaki, Yo, Qayum, Shehzad, Russler, Emilie V., Cavalli, Valeria, Milbrandt, Jeffrey, DiAntonio, Aaron
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535671/
https://ncbi.nlm.nih.gov/pubmed/23188802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216204109
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