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A DLK-dependent axon self-destruction program promotes Wallerian degeneration
Axon degeneration underlies many common neurological disorders, but the signaling pathways that orchestrate axon degeneration are unknown. We demonstrate that the dual leucine kinase (DLK) promotes degeneration of severed axons in Drosophila and mice, and its target JNK promotes degeneration locally...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2696160/ https://ncbi.nlm.nih.gov/pubmed/19287387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2290 |
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