Amyloid Precursor Protein Cleavage-Dependent and -Independent Axonal Degeneration Programs Share a Common Nicotinamide Mononucleotide Adenylyltransferase 1-Sensitive Pathway

Axonal degeneration is a hallmark of many debilitating neurological disorders and is thought to be regulated by mechanisms distinct from those governing cell body death. Recently, caspase 6 activation via amyloid precursor protein (APP) cleavage and activation of DR6 was discovered to induce axon de...

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Hlavní autoři: Vohra, Bhupinder P. S., Sasaki, Yo, Miller, Bradley R., Chang, Jufang, DiAntonio, Aaron, Milbrandt, Jeffrey
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104322/
https://ncbi.nlm.nih.gov/pubmed/20943913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2939-10.2010
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