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A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2), for their maintenance and degenerate rapidly when this acti...
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| Publicado no: | Cell Death Differ |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4392071/ https://ncbi.nlm.nih.gov/pubmed/25323584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.164 |
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