A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2), for their maintenance and degenerate rapidly when this acti...

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Detaylı Bibliyografya
Yayımlandı:Cell Death Differ
Asıl Yazarlar: Di Stefano, M, Nascimento-Ferreira, I, Orsomando, G, Mori, V, Gilley, J, Brown, R, Janeckova, L, Vargas, M E, Worrell, L A, Loreto, A, Tickle, J, Patrick, J, Webster, J R M, Marangoni, M, Carpi, F M, Pucciarelli, S, Rossi, F, Meng, W, Sagasti, A, Ribchester, R R, Magni, G, Coleman, M P, Conforti, L
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Original Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392071/
https://ncbi.nlm.nih.gov/pubmed/25323584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.164
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