A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2), for their maintenance and degenerate rapidly when this acti...

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Publicado en:Cell Death Differ
Main Authors: Di Stefano, M, Nascimento-Ferreira, I, Orsomando, G, Mori, V, Gilley, J, Brown, R, Janeckova, L, Vargas, M E, Worrell, L A, Loreto, A, Tickle, J, Patrick, J, Webster, J R M, Marangoni, M, Carpi, F M, Pucciarelli, S, Rossi, F, Meng, W, Sagasti, A, Ribchester, R R, Magni, G, Coleman, M P, Conforti, L
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392071/
https://ncbi.nlm.nih.gov/pubmed/25323584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.164
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