A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2), for their maintenance and degenerate rapidly when this acti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Differ
Prif Awduron: Di Stefano, M, Nascimento-Ferreira, I, Orsomando, G, Mori, V, Gilley, J, Brown, R, Janeckova, L, Vargas, M E, Worrell, L A, Loreto, A, Tickle, J, Patrick, J, Webster, J R M, Marangoni, M, Carpi, F M, Pucciarelli, S, Rossi, F, Meng, W, Sagasti, A, Ribchester, R R, Magni, G, Coleman, M P, Conforti, L
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Original Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392071/
https://ncbi.nlm.nih.gov/pubmed/25323584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.164
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