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SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration

Axonal degeneration contributes to the pathogenesis of many neurodegenerative disorders, motivating efforts to dissect the mechanism of pathological axon loss in order to develop therapies for axonal preservation. SARM1 is a particularly attractive therapeutic target, as it is an inducible NAD(+) cl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Exp Neurol
Hauptverfasser: Chen, Yi-Hsien, Sasaki, Yo, DiAntonio, Aaron, Milbrandt, Jeffrey
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8171232/
https://ncbi.nlm.nih.gov/pubmed/33548217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2021.113636
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