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SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration

Axonal degeneration contributes to the pathogenesis of many neurodegenerative disorders, motivating efforts to dissect the mechanism of pathological axon loss in order to develop therapies for axonal preservation. SARM1 is a particularly attractive therapeutic target, as it is an inducible NAD(+) cl...

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Bibliografske podrobnosti
izdano v:Exp Neurol
Main Authors: Chen, Yi-Hsien, Sasaki, Yo, DiAntonio, Aaron, Milbrandt, Jeffrey
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8171232/
https://ncbi.nlm.nih.gov/pubmed/33548217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2021.113636
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