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SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration

Axonal degeneration contributes to the pathogenesis of many neurodegenerative disorders, motivating efforts to dissect the mechanism of pathological axon loss in order to develop therapies for axonal preservation. SARM1 is a particularly attractive therapeutic target, as it is an inducible NAD(+) cl...

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Vydáno v:Exp Neurol
Hlavní autoři: Chen, Yi-Hsien, Sasaki, Yo, DiAntonio, Aaron, Milbrandt, Jeffrey
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8171232/
https://ncbi.nlm.nih.gov/pubmed/33548217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2021.113636
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