Wird geladen...
NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD(+) depletion
Overexpression of the NAD(+) biosynthetic enzyme NMNAT1 leads to preservation of injured axons. While increased NAD(+) or decreased NMN levels are thought to be critical to this process, the mechanism(s) of this axon protection remain obscure. Using steady-state and flux analysis of NAD(+) metabolit...
Gespeichert in:
| Veröffentlicht in: | eLife |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2016
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5063586/ https://ncbi.nlm.nih.gov/pubmed/27735788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19749 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|