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NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD(+) depletion
Overexpression of the NAD(+) biosynthetic enzyme NMNAT1 leads to preservation of injured axons. While increased NAD(+) or decreased NMN levels are thought to be critical to this process, the mechanism(s) of this axon protection remain obscure. Using steady-state and flux analysis of NAD(+) metabolit...
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| Publicado en: | eLife |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5063586/ https://ncbi.nlm.nih.gov/pubmed/27735788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19749 |
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