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SARM1 activation triggers axon degeneration locally via NAD+ destruction
Axon degeneration is an intrinsic self-destruction program that underlies axon loss during injury and disease. Sterile alpha and TIR motif containing 1 (SARM1) protein is an essential mediator of axon degeneration. We report that SARM1 initiates a local destruction program involving rapid breakdown...
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| Publicado no: | Science |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4513950/ https://ncbi.nlm.nih.gov/pubmed/25908823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1258366 |
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