Loading...
SARM1 activation triggers axon degeneration locally via NAD+ destruction
Axon degeneration is an intrinsic self-destruction program that underlies axon loss during injury and disease. Sterile alpha and TIR motif containing 1 (SARM1) protein is an essential mediator of axon degeneration. We report that SARM1 initiates a local destruction program involving rapid breakdown...
Saved in:
| Published in: | Science |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4513950/ https://ncbi.nlm.nih.gov/pubmed/25908823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1258366 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|