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Axon self destruction: new links among SARM1, MAPKs, and NAD+ metabolism
Wallerian axon degeneration is a form of programmed subcellular death that promotes axon breakdown in disease and injury. Active degeneration requires SARM1 and MAP kinases including DLK, while the NAD+ synthetic enzyme NMNAT2 prevents degeneration. New studies reveal that these pathways cooperate i...
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| Publicado no: | Neuron |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4742785/ https://ncbi.nlm.nih.gov/pubmed/26844829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.12.023 |
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