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Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions
Axon degeneration is an evolutionarily conserved pathway that eliminates damaged or unneeded axons. Manipulation of this poorly understood pathway may allow treatment of a wide range of neurological disorders. In an RNAi-based screen performed in cultured mouse DRG neurons, we observed strong suppre...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3742939/ https://ncbi.nlm.nih.gov/pubmed/23946415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1197-13.2013 |
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