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Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

Axon degeneration is an evolutionarily conserved pathway that eliminates damaged or unneeded axons. Manipulation of this poorly understood pathway may allow treatment of a wide range of neurological disorders. In an RNAi-based screen performed in cultured mouse DRG neurons, we observed strong suppre...

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Autores principales: Gerdts, Josiah, Summers, Daniel W., Sasaki, Yo, DiAntonio, Aaron, Milbrandt, Jeffrey
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742939/
https://ncbi.nlm.nih.gov/pubmed/23946415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1197-13.2013
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