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Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

Axon degeneration is an evolutionarily conserved pathway that eliminates damaged or unneeded axons. Manipulation of this poorly understood pathway may allow treatment of a wide range of neurological disorders. In an RNAi-based screen performed in cultured mouse DRG neurons, we observed strong suppre...

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Detalhes bibliográficos
Main Authors: Gerdts, Josiah, Summers, Daniel W., Sasaki, Yo, DiAntonio, Aaron, Milbrandt, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742939/
https://ncbi.nlm.nih.gov/pubmed/23946415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1197-13.2013
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