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SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration
Leber congenital amaurosis type nine is an autosomal recessive retinopathy caused by mutations of the NAD(+) synthesis enzyme NMNAT1. Despite the ubiquitous expression of NMNAT1, patients do not manifest pathologies other than retinal degeneration. Here we demonstrate that widespread NMNAT1 depletio...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7591247/ https://ncbi.nlm.nih.gov/pubmed/33107823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62027 |
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