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NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD(+) depletion

Overexpression of the NAD(+) biosynthetic enzyme NMNAT1 leads to preservation of injured axons. While increased NAD(+) or decreased NMN levels are thought to be critical to this process, the mechanism(s) of this axon protection remain obscure. Using steady-state and flux analysis of NAD(+) metabolit...

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Pubblicato in:eLife
Autori principali: Sasaki, Yo, Nakagawa, Takashi, Mao, Xianrong, DiAntonio, Aaron, Milbrandt, Jeffrey
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063586/
https://ncbi.nlm.nih.gov/pubmed/27735788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19749
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