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Neuronal Activity and Secreted Amyloid β Lead to Altered Amyloid β Precursor Protein and Presenilin 1 Interactions

Deposition of amyloid β (Aβ) containing plaques in the brain is one of the neuropathological hallmarks of Alzheimer's disease (AD). It has been suggested that modulation of neuronal activity may alter Aβ production in the brain. We postulate that these changes in Aβ production are due to change...

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Bibliografiske detaljer
Main Authors: Li, Xuejing, Uemura, Kengo, Hashimoto, Tadafumi, Arimon, Muriel, Lill, Christina M., Palazzolo, Isabella, Krainc, Dimitri, Hyman, Bradley T., Berezovska, Oksana
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534898/
https://ncbi.nlm.nih.gov/pubmed/23064434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.10.002
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