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Neuronal Activity and Secreted Amyloid β Lead to Altered Amyloid β Precursor Protein and Presenilin 1 Interactions

Deposition of amyloid β (Aβ) containing plaques in the brain is one of the neuropathological hallmarks of Alzheimer's disease (AD). It has been suggested that modulation of neuronal activity may alter Aβ production in the brain. We postulate that these changes in Aβ production are due to change...

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Detalhes bibliográficos
Main Authors: Li, Xuejing, Uemura, Kengo, Hashimoto, Tadafumi, Arimon, Muriel, Lill, Christina M., Palazzolo, Isabella, Krainc, Dimitri, Hyman, Bradley T., Berezovska, Oksana
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534898/
https://ncbi.nlm.nih.gov/pubmed/23064434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.10.002
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