Closed-loop Continuous Infusions of Etomidate and Etomidate Analogs in Rats: A Comparative Study of Dosing and the Impact on Adrenocortical Function

BACKGROUND: Etomidate is a sedative–hypnotic that is often given as a single intravenous bolus but rarely as an infusion because it suppresses adrenocortical function. Methoxycarbonyl etomidate and (R)-ethyl 1-(1-phenylethyl)-1H-pyrrole-2-carboxylate (carboetomidate) are etomidate analogs that do no...

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Main Authors: Cotten, Joseph F., Le Ge, Ri, Banacos, Natalie, Pejo, Ervin, Husain, S. Shaukat, Williams, James H., Raines, Douglas E.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534755/
https://ncbi.nlm.nih.gov/pubmed/21572317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e31821950de
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