Disposition of Caspofungin: Role of Distribution in Determining Pharmacokinetics in Plasma

The disposition of caspofungin, a parenteral antifungal drug, was investigated. Following a single, 1-h, intravenous infusion of 70 mg (200 μCi) of [(3)H]caspofungin to healthy men, plasma, urine, and feces were collected over 27 days in study A (n = 6) and plasma was collected over 26 weeks in stud...

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Autores principales: Stone, Julie A., Xu, Xin, Winchell, Gregory A., Deutsch, Paul J., Pearson, Paul G., Migoya, Elizabeth M., Mistry, Goutam C., Xi, Liwen, Miller, Alisha, Sandhu, Punam, Singh, Romi, deLuna, Florencia, Dilzer, Stacy C., Lasseter, Kenneth C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC353127/
https://ncbi.nlm.nih.gov/pubmed/14982770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.3.815-823.2004
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