Antifungal Efficacy of Caspofungin (MK-0991) in Experimental Pulmonary Aspergillosis in Persistently Neutropenic Rabbits: Pharmacokinetics, Drug Disposition, and Relationship to Galactomannan Antigenemia

The antifungal efficacy, pharmacokinetics, and safety of caspofungin (CAS) were investigated in the treatment and prophylaxis of invasive pulmonary aspergillosis due to Aspergillus fumigatus in persistently neutropenic rabbits. Antifungal therapy consisted of 1, 3, or 6 mg of CAS/kg of body weight/d...

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Bibliografische gegevens
Hoofdauteurs: Petraitiene, Ruta, Petraitis, Vidmantas, Groll, Andreas H., Sein, Tin, Schaufele, Robert L., Francesconi, Andrea, Bacher, John, Avila, Nilo A., Walsh, Thomas J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2002
Onderwerpen:
Experimental Therapeutics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC127008/
https://ncbi.nlm.nih.gov/pubmed/11751105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.1.12-23.2002
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