Antifungal Activity of LY303366, a Novel Echinocandin B, in Experimental Disseminated Candidiasis in Rabbits

The safety and antifungal activity of LY303366 (LY), a new broad-spectrum semisynthetic echinocandin, were studied against disseminated candidiasis in persistently neutropenic rabbits. In vitro time-kill assays demonstrated that LY has concentration-dependent fungicidal activity. The pharmacokinetic...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Petraitiene, Ruta, Petraitis, Vidmantas, Groll, Andreas H., Candelario, Myrna, Sein, Tin, Bell, Aaron, Lyman, Caron A., McMillian, Carl L., Bacher, John, Walsh, Thomas J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Experimental Therapeutics
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89438/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10471556/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.9.2148
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