Antifungal Activity of LY303366, a Novel Echinocandin B, in Experimental Disseminated Candidiasis in Rabbits

The safety and antifungal activity of LY303366 (LY), a new broad-spectrum semisynthetic echinocandin, were studied against disseminated candidiasis in persistently neutropenic rabbits. In vitro time-kill assays demonstrated that LY has concentration-dependent fungicidal activity. The pharmacokinetic...

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Main Authors: Petraitiene, Ruta, Petraitis, Vidmantas, Groll, Andreas H., Candelario, Myrna, Sein, Tin, Bell, Aaron, Lyman, Caron A., McMillian, Carl L., Bacher, John, Walsh, Thomas J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC89438/
https://ncbi.nlm.nih.gov/pubmed/10471556
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