Antifungal Efficacy of Caspofungin (MK-0991) in Experimental Pulmonary Aspergillosis in Persistently Neutropenic Rabbits: Pharmacokinetics, Drug Disposition, and Relationship to Galactomannan Antigenemia

The antifungal efficacy, pharmacokinetics, and safety of caspofungin (CAS) were investigated in the treatment and prophylaxis of invasive pulmonary aspergillosis due to Aspergillus fumigatus in persistently neutropenic rabbits. Antifungal therapy consisted of 1, 3, or 6 mg of CAS/kg of body weight/d...

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Hauptverfasser: Petraitiene, Ruta, Petraitis, Vidmantas, Groll, Andreas H., Sein, Tin, Schaufele, Robert L., Francesconi, Andrea, Bacher, John, Avila, Nilo A., Walsh, Thomas J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC127008/
https://ncbi.nlm.nih.gov/pubmed/11751105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.1.12-23.2002
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