Disposition of Caspofungin: Role of Distribution in Determining Pharmacokinetics in Plasma

The disposition of caspofungin, a parenteral antifungal drug, was investigated. Following a single, 1-h, intravenous infusion of 70 mg (200 μCi) of [(3)H]caspofungin to healthy men, plasma, urine, and feces were collected over 27 days in study A (n = 6) and plasma was collected over 26 weeks in stud...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Stone, Julie A., Xu, Xin, Winchell, Gregory A., Deutsch, Paul J., Pearson, Paul G., Migoya, Elizabeth M., Mistry, Goutam C., Xi, Liwen, Miller, Alisha, Sandhu, Punam, Singh, Romi, deLuna, Florencia, Dilzer, Stacy C., Lasseter, Kenneth C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2004
Soggetti:	Pharmacology
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC353127/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14982770/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.3.815-823.2004
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