Centrally Acting Oximes in Reactivation of Tabun-Phosphoramidated AChE

Organophosphates (OP) inhibit acetylcholinesterase (AChE, E.C.3.1.1.7), both in peripheral tissues and central nervous system (CNS), causing adverse and sometimes fatal effects due to the accumulation of neurotransmitter acetylcholine (ACh). The currently used therapy, focusing on the reactivation o...

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Detalhes bibliográficos
Main Authors: Kovarik, Zrinka, Maček, Nikolina, Sit, Rakesh K., Radić, Zoran, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530643/
https://ncbi.nlm.nih.gov/pubmed/22960624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2012.08.019
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